ABSTRACT
Purpose:To study the efficacy of preoperative selective intra arterial chemotherapy in advanced gastric carcinoma. Methods:Between August 1999 and November 2001, a total of 98 hospitalized patients with advanced gastric carcinoma who underwent selective intra arterial regional chemotherapy prior to surgery were recruited in this study. 60 patients with advanced gastric carcinoma on whom surgery were performed did not receive any preoperative regional anti cancer drugs between 1997 and 1998 and served as controls. The surgical resection rate and histologic investigations were compared. Results:The resection rate was 78% in regional chemotherapy group and 68% in control group. Tumor cell necrosis was investigated by postoperative pathological study and revealed that the response rate in regional chemotherapy group was 67%. Only 8 cases in control group showed mild focal necrosis. Conclusions:Preoperative regional chemotherapy in patients with advanced gastric carcinoma may enhance resection rate and destroy large numbers of tumor cells vigorously. The preliminary results are satisfying.
ABSTRACT
Objective To evaluate radio frequency hyperthemia combined with intrahepatic arterial chemotherapy in the treatment of advanced liver cancer. Methods 50 cases of primary or secondary advanced liver concers were selected and treated with chemotherapeutic perfusion or chemoembolization via hepatic artery by the method of Seldinger, combining synergetically radio frequency heat therapy for achieving better efficacy. Results Clinical conditions in 18 of 509 cases were improved with ? fetoprotein returned to negative in 6 cases and decreased in 13 Ultrasound or CT demonstrated tumor shrinkage in 18 cases. Conclusions Radio frequency hyperthermia combined with interventional chemotherapy via hepatic artery is effective in the treatment of advanced liver cancer together with no obvious side effects.